Antimicrobial, synergistic and antibiofilm activities of Myristica fragrans Houtt. Bioactive compounds and their derivatives.

ABSTRACT: This study investigates the antimicrobial efficacy, synergistic interactions, antibiofilm activity, molecular docking studies, and drug-likeness properties of α-terpineol, 4-carvomenthenol, and their derivatives isolated from nutmeg and mace (Myristica fragrans Houtt.). α-Terpineol and 4-carvomenthenol were isolated from nutmeg essential oil and mace oleoresin respectively using column chromatography. Derivatization of α-Terpineol was derivatized into its ester, epoxide, ether, and allylic bromide while 4-carvomenthenol was derivatized to form its ester and epoxide. The antimicrobial activity of isolated compounds and their derivatives was assessed against Bacillus sp., Staphylococcus aureus, Yersinia enterocolitica and Escherichia coli followed by testing of their synergistic interactions

SUBMITTER: Kaur V 

PROVIDER: S-EPMC12474920 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature