Gtf2i-encoded transcription factor Tfii-i regulates myelination via Sox10 and Mbp regulatory elements.

ABSTRACT: The transcriptional regulatory network governing the differentiation and functionality of oligodendrocytes (OLs) is essential for the formation and maintenance of the myelin sheath, and hence for the proper function of the nervous system. Perturbations in the intricate interplay of transcriptional effectors within this network can lead to a variety of nervous system pathologies. In this study, we identify Gtf2i-encoded general transcription factor II-I (Tfii-i) as a regulator of key myelination-related genes. Gtf2i deletion from myelinating glial cells in male mice leads to functional alterations in central nervous system (CNS) myelin, including elevated mRNA and protein expression levels of myelin basic protein (Mbp), the central myelin component, enhanced connectivity properties, and thi

SUBMITTER: Levy G 

PROVIDER: S-EPMC12474925 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature