White matter neural substrates in alcohol dependence with genetic risk and their role in pathological reward process.

ABSTRACT: Studies have revealed significant evidence of white matter (WM) microstructural and network connectome abnormalities in alcohol use disorder (AUD). However, the neuroimaging characteristics of alcohol dependence (AD) patients with a family history of AUD and the role of these changes in pathological craving remain unclear. Investigating the heritability of AUD is crucial for identifying genetic predispositions and informing targeted prevention strategies. The study recruited 51 patients for AD, 21 patients with a family history positive (FHP), 30 patients with a family history negative (FHN), and 25 healthy controls (HC). We compared fractional anisotropy (FA) and mean diffusivity (MD) of striatal circuits and topological properties of the reward system between the three groups. Then, cova

SUBMITTER: Wu F 

PROVIDER: S-EPMC12474950 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature