Combined albumin and CEA improve prognostic prediction in resectable gastric cancer.

ABSTRACT: Preoperative high levels of serum carcinoembryonic antigen (CEA) and low levels of albumin (ALB) are closely related to poor prognosis among patients with gastric cancer. This study aims to determine the prognostic value of preoperative serum ALB plus CEA levels as a new biomarker in patients with resectable gastric cancer. This retrospective cohort study included 329 patients with gastric cancer. The optimal cutoff values of ALB and CEA were 4.77 ng/mL and 41.47 g/L, respectively. Patients were stratified into three groups based on these cutoff values: ALB-CEA = 0 (ALB > 41.47 g/L and CEA ≤ 4.77 ng/mL), ALB-CEA = 1 (ALB ≤ 41.47 g/L or CEA > 4.77 ng/mL), and ALB-CEA = 2 (ALB ≤ 41.47 g/L and CEA > 4.77 ng/mL). Kaplan-Meier curve and Cox proportional model were used to determine the predicti

SUBMITTER: Li J 

PROVIDER: S-EPMC12474952 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature