Cathepsin B in human peripheral blood lymphocytes as a peripheral biomarker for cardiac hypertrophy.

ABSTRACT: Previous studies have demonstrated that cathepsin B is up-regulated in the myocardium of both mice and humans with pathological cardiac hypertrophy. However, it remains unknown whether cathepsin B is detectable in human peripheral blood lymphocytes (PBLs) and whether its expression is associated with pathological hypertrophy. In this study, immunofluorescence staining confirmed the presence of cathepsin B in human PBLs. Western blotting analysis and correlation studies further revealed a positive correlation between cathepsin B protein levels in PBLs and that in cardiac tissues (r = 0.441, p = 0.017). We also investigated the association between cathepsin B expression level in PBLs and cardiac structure and function. Quantitative PCR and western blotting analyses indicated that patients wi

SUBMITTER: Feng D 

PROVIDER: S-EPMC12475020 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature