UCP3 gene variants and obesity in a Pakistani sample population.

ABSTRACT: Obesity is a growing public health challenge with complex causes involving both environmental and genetic factors. This study explored the contribution of genetic variants in the UCP3 gene (implicated in energy metabolism) to obesity risk in a Pakistani population. Using a case-control design, 400 participants from Karachi (200 cases-individuals with obesity; 200 controls-individuals with normal body mass index or BMI) were assessed for sociodemographic, obesity-related physical signs, comorbidities, anthropometric, metabolic, and lifestyle factors, alongside next-generation sequencing of the UCP3 gene. Individuals with obesity (cases) were more frequently married, had a family history of obesity, and exhibited obesity-related physical signs compared to controls. All anthropometric (except

SUBMITTER: Bhatti AA 

PROVIDER: S-EPMC12475033 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature