Integrative analysis of molecular mechanisms in prostate cancer via single-cell RNA sequencing and weighted gene co-expression network analysis.

ABSTRACT: Despite extensive prior research on prostate cancer (PCa) transcriptomics, the molecular mechanisms underlying the disease's progression, particularly in the castration-resistant or metastatic stages, remain incompletely understood. The majority of recent research has concentrated on bulk RNA sequencing, which could mask the variation found in tumor microenvironments. This study aims to address this gap by integrating single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing with weighted gene co-expression network analysis (WGCNA) to investigate the molecular mechanisms of PCa at a higher resolution. In order to further individualized treatment plans for PCa, we aim to discover important genes and signaling pathways that could be used as therapeutic targets. We first preprocessed exp

SUBMITTER: Zhai J 

PROVIDER: S-EPMC12475054 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature