Multiomics Mendelian randomization integrating pQTL, eQTL and mQTL data revealed BTN3A2 as a potential drug target for nephrolithiasis.

ABSTRACT: Nephrolithiasis has a high recurrence rate and imposes a heavy burden on patients and society. Therefore, there is an urgent need to explore new effective targets for nephrolithiasis prevention and treatment. Protein quantitative trait loci (pQTL) data of plasma proteins and plasma protein-protein ratios were used as plasma protein related targets (PPRTs), and genome-wide association studies (GWASs) of nephrolithiasis were used as outcomes. Bidirectional Mendelian randomization analyses were then conducted. The mediating factors between PPRTs and nephrolithiasis were identified. After colocalization analyses, the safety of targeted PPRTs for nephrolithiasis were evaluated. Subsequently, multi-omics data were used to further validate the effects of candidate PPRTs on nephrolithiasis. Finall

SUBMITTER: Sun S 

PROVIDER: S-EPMC12475057 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature