Cross-Sectional and Longitudinal Immunoprofiling of Oligoarticular Juvenile Idiopathic Arthritis Reveals Different Patterns in Synovial Fluid and Plasma.

ABSTRACT: Oligoarticular juvenile idiopathic arthritis (oligoJIA) constitutes nearly 60% of all JIA cases. The immune mechanisms involved in the pathogenesis remain incompletely understood. Few proteomic studies have been performed using synovial fluid (SF) samples. We conducted an exploratory analysis of plasma and SF samples to define inflammatory profiles, assess plasma-SF correlation and examine longitudinal variations. Using proximity extension assay (PEA), we profiled 92 immune-related proteins in plasma and Sf from 14 oligoJIA patients (untreated or NSAID-treated) and plasma from 28 age and sex-matched healthy controls. Differentially expressed proteins were analysed using gene ontology (GO) and KEGG pathways via STRING. Plasma proteomic immune profiles from oligoJIA patients were highly over

SUBMITTER: Qu H 

PROVIDER: S-EPMC12475091 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature