LncRNA HOXA11-AS promotes the cell proliferation, migration, invasion and inhibits cell apoptosis in esophageal squamous cell carcinoma.

ABSTRACT: This study aimed to investigate the expression and evaluate the function of long non-coding RNA (LncRNA) HOXA11-AS in Esophageal Squamous Cell Carcinoma (ESCC). HOXA11-AS expression was quantified in paired ESCC tumor tissues (n = 50) and adjacent histologically normal tissues (> 5 cm from tumor margin) (n=50) from surgical patients. The relationship between HOXA11-AS expression levels, clinical staging and patient survival was analyzed. Lentiviral transduction was employed to generate stable ESCC cell lines with HOXA11-AS overexpression (lv-HOXA11-AS) or knockdown (sh-HOXA11-AS), accompanied by negative control groups (lv-NC/sh-NC). The impact on malignant phenotype was assessed via CCK-8 proliferation assays, Transwell migration/invasion assays, wound healing assays, and flow cytometry f

SUBMITTER: Li W 

PROVIDER: S-EPMC12475127 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature