Hypoxic conditioning in Parkinson's disease: randomized controlled multiple N-of-1 trials.

ABSTRACT: Preclinical evidence suggests positive symptomatic and neuroprotective effects of hypoxic conditioning in Parkinson's disease (PD). This study (NCT05214287) investigated the safety, feasibility, short-term symptomatic and downstream effects of hypoxic conditioning in individuals with PD. 20 individuals with PD (mean age 62, 10 women, Hoehn-Yahr 1.5-3) completed randomized controlled double-blinded multiple N-of-1 trials. Each participant underwent five different 45-minute hypoxia interventions in duplicate: continuous hypoxia at FiO₂ 0.163 and 0.127, intermittent (five-minute intervals interspersed with normoxia) at FiO₂ 0.163 and 0.127, and placebo. Primary outcomes were safety and feasibility as measured by adverse events, vital parameter disturbances, participant-r

SUBMITTER: Janssen Daalen JM 

PROVIDER: S-EPMC12475152 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature