Investigating the role of the ALPK1 signaling pathway in the pathogenesis of diabetic retinopathy.

ABSTRACT: Diabetic retinopathy (DR) is a key eye-related complication linked to diabetes. Chronic inflammation is recognized as the main pathological mechanism leading to retinal damage during the onset and progression of DR. Alpha kinase 1 (ALPK1), a member of a recently discovered serine/threonine protein kinase family, is associated with the onset of multiple inflammatory conditions. Dominant mutations in the ALPK1 gene can result in a rare genetic disorder, known as ROSAH syndrome, which is characterized by ocular inflammatory responses. The role of ALPK1 in DR remains largely unclear and necessitates additional research for a better understanding. Therefore, investigating the function and underlying mechanisms of ALPK1 in DR is highly necessary. In this research, ALPK1 expression and inflammato

SUBMITTER: Wu T 

PROVIDER: S-EPMC12475159 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature