Genetic susceptibility to oral and atherosclerotic cardiovascular diseases based on dental and heart SCORE studies.

ABSTRACT: Periodontal disease and dental caries are two oral conditions that have been associated with atherosclerotic cardiovascular disease (ASCVD). However, it is unclear if one of the key mechanisms involved in this association could be a shared genetic susceptibility. The goal of this study was to explore whether there is an intersection of genetic loci among individuals with comprehensive oral examinations and subclinical ASCVD screenings. We leveraged data from oral and medical examinations obtained from the Dental and Heart Strategies Concentrating on Risk Evaluation (Dental/Heart SCORE) projects. Genome-wide association studies (GWASs) were performed independently in 552 participants (aged 45-75 years). The decayed, missing, or filled teeth index (DMFT) and periodontal disease indices were

SUBMITTER: Bezamat M 

PROVIDER: S-EPMC12475168 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature