Lanthanum exposure and its metabolomic effects on Ruditapes philippinarum.

ABSTRACT: The growing release of rare earth elements (REEs) into aquatic environments, driven by their extensive industrial and technological applications, has raised growing concern due to their largely unknown ecological and toxicological effects. Among these, lanthanum (La), one of the most widely used REEs, is increasingly detected in marine ecosystems. This study investigates the short-term impact of exposure on the Manila clam, Ruditapes philippinarum, a key benthic species in Mediterranean aquaculture. Clams were exposed to 10 mg/L of LaCl₃·7 H₂O, and their gill tissues were analyzed through histological examination and untargeted metabolomics. Histological analysis revealed epithelial degeneration, decreased mucus secretion, and altered glycoprotein expression following exposure. Metabolomic

SUBMITTER: Mastrorocco F 

PROVIDER: S-EPMC12475223 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature