Diagnostic performance of HIV risk assessment tools for identifying pre-exposure prophylaxis candidates: a systematic review and meta-analysis.

ABSTRACT:

Background

To support the implementation of HIV pre-exposure prophylaxis (PrEP), we conducted a systematic review and meta-analysis evaluating the diagnostic performance of HIV risk assessment tools in predicting HIV infection.

Methods

We searched MEDLINE, Embase, and CINAHL for observational studies published between January 1, 1998, and May 13, 2024 that reported on the diagnostic performance of HIV risk assessment tools. We calculated pooled area under the curve (pAUC) values using inverse variance methods, with sensitivity and specificity reported at common cutoffs (PROSPERO registration number: CRD42024543975).

Findings

Of 3704 publications, 27 met our criteria. Twelve studies on men who have sex with men (MSM) assessed nine tools, with four extensively validated

SUBMITTER: Oo MM 

PROVIDER: S-EPMC12475485 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature