Comprehensive characterization of lysosome-dependent cell death reveals prognostic significance and immune landscape in colon adenocarcinoma.

ABSTRACT: Lysosome-dependent cell death (LDCD) is an emerging form of regulated cell death with critical implications in tumor development, immune modulation, and therapy responsiveness. However, the role of LDCD-related genes in colon adenocarcinoma (COAD) remains poorly understood. We comprehensively analyzed LDCD-related gene expression profiles using transcriptomic data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases (GEO). Unsupervised clustering was performed to identify molecular subtypes. A prognostic signature was developed using LASSO and Cox regression analyses. Immune infiltration characteristics and immunotherapy responses were assessed via multiple algorithms. Single-cell RNA sequencing (scRNA-seq) analysis was conducted to explore the cellular distribution of

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12475495 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature