Development of a Core Outcome Set for Intervention Studies in Adults With Laryngotracheal Stenosis.

ABSTRACT:

Objective

Adult acquired laryngotracheal stenosis (LTS) is a chronic condition with heterogeneous treatment options and a significant symptom burden. Synthesis of data across research studies to guide clinical decision-making is challenging due to inconsistent outcome selection and use of unvalidated measures. Our objective was to establish a core outcome set (COS) for studies of LTS interventions in adults.

Methods

We conducted a two-round modified e-Delphi study. We reviewed published systematic reviews and qualitative studies to inform the inclusion of 42 outcomes in the first e-Delphi round, with 10 additional outcomes added by participants for the second voting round. The international expert panel included clinicians, researchers, and people living with LTS. We held tw

SUBMITTER: Clunie GM 

PROVIDER: S-EPMC12475546 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature