Therapeutic potential of 5HT2CR in alleviating spasticity and pain via modulation of motor neurons and interneurons in spinal cord injury.

ABSTRACT: Numerous adverse outcomes can be resulted in limb spasm and spasticity that occur after spinal cord injury (SCI). Here, we used adeno-associated virus (AAV) vectors and Cre-driver transgenic mice to selectively overexpress 5-hydroxytryptamine2C receptor (5HT2CR) in motor, GABAergic, and Glutamatergic interneurons. Targeted overexpression in these neuronal populations attenuated spasticity-like responses and hindlimb motor deficits, and improved sensory abnormalities and affective disturbances. These behavioral improvements were associated with changes in potassium chloride cotransporter-2 (KCC2), gamma-aminobutyric acid type A receptor (GABAAR), and N-methyl-D-aspartate receptor (NMDAR) expression in spinal cord tissue, indicating that the activity of motor neurons is influenced by the exp

SUBMITTER: Gong H 

PROVIDER: S-EPMC12475576 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature