Turning Waste Into Insight: A Novel Proteomic Approach to Non-Invasive Wound Biomarker Discovery.

ABSTRACT: Chronic wounds such as diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) are a growing public health burden, contributing to significant morbidity, healthcare costs, and mortality. Current management strategies are hampered by the inability to accurately predict healing trajectories or identify early treatment failures. Here, we present a novel, non-invasive proteomic approach that leverages routinely discarded wound dressings to profile the wound microenvironment across soluble, cellular, and extracellular vesicle (EV) compartments. Using a cohort of patients with DFU and VLU (n = 16), we performed spatially resolved, longitudinal sampling over 4 weeks and identified distinct proteomic signatures associated with healing versus non-healing outcomes. Mass spectrometry revealed more t

SUBMITTER: Soto V 

PROVIDER: S-EPMC12475851 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature