Evaluation of PD-L1 Expression in Patients With Non-Small Cell Lung Cancer Using DCE-MRI Quantitative Analysis.

ABSTRACT:

Purpose

The aim is to evaluate the expression of programmed death ligand 1 (PD-L1) in patients with non-small cell lung cancer (NSCLC) using quantitative perfusion parameters based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).

Methods

A total of 35 patients with a confirmed diagnosis of NSCLC and sufficient tissue pathology were enrolled in the study. The immunohistochemical (IHC) results were used as the gold standard to determine the thresholds for grouping the patients. The patients were divided into three categories based on their PD-L1 expression: (1) PD-L1-negative (IHC < 1%) and PD-L1-positive (IHC ≥ 1%); (2) PD-L1 weak (IHC < 50%) and strong expression (IHC ≥ 50%); and (3) PD-L1 nonexpression (IHC < 1%), low expression (IHC between 1% and 49%), a

SUBMITTER: Yang C 

PROVIDER: S-EPMC12475933 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature