Deteriorated Gray Matter Connectome in Diabetic Kidney Disease: A Graph Theory Analysis of Individual-Level Gray Matter Morphological Networks.

ABSTRACT:

Introduction

Cognitive impairment is frequently observed in patients with diabetes mellitus (DM), and this condition worsens in those with diabetic kidney disease (DKD). However, the precise neural mechanisms involved are still not fully understood. The present study aimed to investigate the topological organization of individual-level gray matter (GM) structural networks in patients with DKD and its association with clinical characteristics.

Methods

Structural magnetic resonance imaging data were collected from 50 DKD patients, 65 DM patients, and 70 healthy controls (HCs). Following data processing, individualized similarity-based GM morphological networks were created. The topological properties of these networks were analyzed using graph theory analysis and compared amon

SUBMITTER: Guo F 

PROVIDER: S-EPMC12475994 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature