Radiomics-Based Prognostication in Primary Sclerosing Cholangitis: A Proof-of-Concept Study.

ABSTRACT:

Background and aim

Risk assessment in primary sclerosing cholangitis (PSC) by magnetic resonance imaging (MRI) relies on semi-quantitative analysis, which can result in interpretation variability. Radiomics may offer a quantitative approach for risk stratification. This study aims to explore and validate MRI-derived radiomic features to identify high-risk PSC patients.

Methods

In this prospective study (January 2019-December 2022), consecutive PSC patients undergoing routine gadoxetate disodium-enhanced MRI were recruited. Using PyRadiomics, whole liver parenchyma features were extracted from five MRI sequences according to the Image Biomarker Standardisation Initiative (IBSI). Patients were categorised into risk groups based on the Mayo risk score (MRS) and liver stiffness

SUBMITTER: Cristoferi L 

PROVIDER: S-EPMC12476022 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature