High-Density Lipoprotein Cardioprotection Function Deteriorates as Women Transition Through Menopause: The SWAN HDL Study.

ABSTRACT:

Background

Women show a rise in high-density lipoprotein cholesterol efflux capacity (CEC) as they traverse menopause. Whether this rise is associated with a lower risk of cardiovascular disease overtime is not clear.

Objectives

The authors tested whether CEC association with subclinical vascular health, measured using a composite subclinical vascular health score based on levels of carotid intima-media thickness, carotid-femoral pulse wave velocity, and presence of coronary artery calcium score (>10), varies by time relative to the final menstrual period (FMP).

Methods

279 women (baseline age 51 ± 2.8 years; 68.5% White) who had CEC and outcome measures were included. The subclinical vascular health measures were related to CEC through a Bayesian hierarchical linear

SUBMITTER: El Khoudary SR 

PROVIDER: S-EPMC12476108 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature