The Immunologic Underpinnings of Post-Stroke Depression.

ABSTRACT: Post-stroke depression is a common consequence of stroke with an estimated prevalence of approximately 30% in stroke patients. It negatively impacts both rehabilitation and quality of life after stroke. Stroke induces an acute activation of the immune system in the central nervous system with concomitant immunologic alterations in the periphery. Immunologic alterations have been associated with non-stroke-related depression, and the evidence points to both central and peripheral immune activation with bidirectional interactions. By identifying and evaluating the current evidence of immunologic alterations associated with depression, stroke, and post-stroke depression, we outline the current knowledge and hypotheses on stroke-related immunologic alterations and associations with the subsequ

SUBMITTER: Sorensen NV 

PROVIDER: S-EPMC12476111 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature