Heterogeneous <i>Salmonella</i> typhi transmission within a household: genomic insights from a chronic carrier.

ABSTRACT: Introduction. Household outbreaks of Salmonella enterica serovar Typhi (S. Typhi) typically involve genetically similar strains, often within a 0-5 single-nucleotide polymorphism (SNP) single linkage cluster. However, unusual genetic heterogeneity may indicate more complex transmission dynamics. This case represents an instance of household transmission facilitated by an asymptomatic carrier harbouring genetically diverse S. Typhi strains. A healthy adult developed severe typhoid requiring hospitalization, and two children required treatment. Public health epidemiological connections among the cases supported the findings of the phylogenetic analysis.Hypothesis/Gap Statement. We hypothesized that a household cluster of S. Typhi infections, displayi

SUBMITTER: Hussain R 

PROVIDER: S-EPMC12476145 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature