Pyruvate kinase M2 modulates Japanese encephalitis virus replication in neuronal cells.

ABSTRACT: Japanese encephalitis is a neuroinflammatory condition caused by the Japanese encephalitis virus (JEV). Pyruvate kinase muscle isozyme M2 (PKM2) is a key modulator of glucose metabolism. The role of PKM2 in the autoimmune response and inflammation is now increasingly being acknowledged. However, its role in modulating virus replication has not been explored. In the current study, we have explored the role of PKM2 in JEV replication. Our results show that endogenous PKM2 expression is significantly upregulated in JEV-infected mouse neuroblastoma cells. Moreover, overexpression and knockdown studies substantiate the negative effect of PKM2 on JEV replication. Additionally, JEV infection induced signal transducers and activators of transcription 3 (STAT3) activation in the infected neuronal c

SUBMITTER: Bohara VS 

PROVIDER: S-EPMC12476147 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature