Comparative genome analysis of human pathogen <i>Parvimonas micra</i> revealed strain JM503A as potential novel species in the genus <i>Parvimonas</i> and high intra-species functional diversity.

ABSTRACT: Parvimonas micra is a Gram-positive, anaerobic bacterium commonly found in the oral cavity, skin and gastrointestinal tract. While typically a harmless organism, it can cause infections in individuals with weakened immune systems, leading to conditions like periodontitis and deep-tissue abscesses. This study focuses on the comparative genomic analysis of P. micra to explore its evolutionary relationships, antimicrobial resistance profiles and functional diversity by assessing phylogenetic analyses, resistance genes, virulence factors, mobile genetic elements, carbohydrate-active enzymes and pan-genome analysis. Comparative genomic analysis of 11 P. micra strains reveals significant functional variations among the strains, indicating notable interspecies diversity. Phyl

SUBMITTER: Suresh R 

PROVIDER: S-EPMC12476148 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature