Casein kinase 1 family member CSNK1E can regulate proliferation and migration in hepatocellular carcinoma.

ABSTRACT:

Purpose

Some studies have shown that circadian rhythms are associated with the development and progression of hepatocellular carcinoma (HCC). In this study, we aimed to elucidate the characterization, prognostic significance and targeting value of circadian rhythm gene CSNK1E in HCC.

Methods

In this study, relevant datasets were downloaded from TCGA and GEO databases and analyzed for differences respectively. The key modules of the prognosis-related gene set were identified using WGCNA, and the intersection of the key module genes with 48 circadian rhythm genes was taken and analyzed in single-cell data. The identification of key circadian rhythm genes in HCC aimed to analyze the expression, prognostic significance, and clinically relevant features of CSNK1E in cancer. The e

SUBMITTER: Zhou J 

PROVIDER: S-EPMC12476353 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature