Bacterial Pneumonia Alters the Respiratory Microbiota and Inflammatory Profile Via the Lung Microbiome-Immune Axis.

ABSTRACT: Bacterial invasion of the lungs causes pneumonia, which poses a serious threat to public health. In the absence of pathogen identification, the misuse of antibacterial agents contributes to bacterial resistance. This study investigated changes in the respiratory microbiome and proinflammatory profiles in bronchoalveolar lavage fluid (BALF) from patients with bacterial pneumonia before and after treatment, compared with healthy controls. Leukocyte count, granulocyte count, and neutrophil percentage were significantly elevated in patients with bacterial pneumonia. Microbial species richness in the untreated pneumonia group (group A) was significantly lower than in the treated group (group B) and healthy controls (group C). Significant differences in α-diversity and β-diversity were observed

SUBMITTER: Ye X 

PROVIDER: S-EPMC12476438 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature