Relationships between GABA + and Glx concentrations with age and inhibition in healthy older adults.

ABSTRACT: Inhibition represents a core executive function which underlies the ability to suppress interfering or distracting stimuli, thereby building resistance against task-irrelevant information. However, the impact of ageing on inhibitory functioning and the role of neuroplasticity - largely driven by predominant excitatory (glutamatergic) and inhibitory (GABAergic) neurochemicals - remains poorly understood. This study investigated age relationships with neurochemical concentrations (GABA + and Glx) and their associations with inhibitory sub-components in healthy ageing. Participants completed three inhibition tasks (flanker, Stroop, go/no-go), each measuring a different sub-component process, via the PsyToolkit platform. MRS data were acquired in the sensorimotor (SM1; n = 71, mean age (SD) = 

SUBMITTER: Treacy C 

PROVIDER: S-EPMC12476448 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature