Effects of Internal and External Cues on Brain Activity and Gait in Parkinson's Disease: Findings From BARC-PD.

ABSTRACT: BackgroundInternal and external cueing strategies are often applied to alleviate gait deficits in Parkinson's disease (PD). However, it remains unclear which type of cueing strategy is most effective at different disease stages. The underlying neural mechanisms of response to cueing are also unknown.ObjectiveTo investigate the immediate response of multiple brain cortical regions and gait to internal and external cueing in people at different stages of PD.MethodsPeople with PD (n = 80) were split into groups dependent on their disease stage (Hoehn and Yahr [H&Y] stage I to III). Participants performed a baseline walk without cues followed by randomized cued walking conditions (internal and external [visual, auditory and tactile] cues). A combined functional near-infrared spectroscopy (fNIR

SUBMITTER: Vitorio R 

PROVIDER: S-EPMC12476477 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature