A recurrence risk score model evaluating effects of postmastectomy radiotherapy in breast cancer patients with pathologically negative lymph nodes after neoadjuvant chemotherapy: a multicenter, retrospective study.

ABSTRACT:

Background

The role of postmastectomy radiotherapy (PMRT) in breast cancer patients achieving pathologically negative lymph nodes (ypN0) after neoadjuvant chemotherapy (NAC) remains controversial due to heterogeneous recurrence risks and lack of prospective evidence.

Objectives

To evaluate the effects of PMRT in ypN0 patients after NAC.

Design

Multicenter retrospective study.

Methods

Data of 624 breast cancer patients with ypN0 was assessed to establish a recurrence risk score model based on a disease-free survival (DFS) rate-based multivariate Cox model. Moreover, the locoregional control (LRC), DFS, and overall survival (OS) rates in PMRT and non-PMRT patients were calculated using the Kaplan-Meier method.

Results

All patients received a median of four

SUBMITTER: Wang DQ 

PROVIDER: S-EPMC12476500 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature