Management and Outcomes of Clostridioides difficile Infection in Patients on Immune Checkpoint Inhibitors.

ABSTRACT:

Background

Data on the severity, management, and outcomes of Clostridioides difficile infection (CDI) in patients presenting with diarrhea while receiving immune checkpoint inhibitors (ICIs) are limited. This study aimed to evaluate the course of CDI in this population and the overlapping diagnosis of immune-related enterocolitis (irEC).

Methods

This retrospective cohort included ICI-treated patients who presented with diarrhea and underwent CDI stool nucleic acid amplification PCR testing at Memorial Sloan Kettering Cancer Center between July 2015 and July 2021. Primary outcomes included CDI frequency, treatment regimens, and the need for immunosuppression for irEC.

Results

Among 605 ICI-treated patients presenting with diarrhea, 111 (18%) tested positive for CDI. Of

SUBMITTER: Magahis PT 

PROVIDER: S-EPMC12476593 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature