Pulvinar and Ventral Thalamic Nuclei Changes Occur Early Along the Psychosis Spectrum.

ABSTRACT:

Background

Psychosis may be conceptualized as a spectrum disorder, with psychotic experiences (PEs), fleeting, subtle symptoms not warranting clinical presentation-at its mildest end. The thalamus, particularly its pulvinar region, is implicated in coordinating cortical synchrony and attention, and may contribute to psychosis. Reduced pulvinar volumes have been observed in severe psychosis and in individuals lower on the spectrum. This study examines thalamic nuclei changes in young adolescents with PEs.

Methods

A community-based sample of 95 adolescents aged 11-13 years (53 with PEs, 42 healthy controls) underwent magnetic resonance imaging (MRI), with thalamic nuclei volumes calculated using Freesurfer. Magnetic resonance imaging (MRI) was repeated at 2- and 5-year follow-

SUBMITTER: Browne C 

PROVIDER: S-EPMC12476835 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature