Body mass index and gastric cancer risk: results from the Stomach Cancer Pooling Project Consortium.

ABSTRACT:

Background

Body mass index (BMI) has been associated with gastric cancer (GC), though results are conflicting regarding the GC subsites of cardia and non-cardia. This study aims to evaluate the associations between BMI and GC risk, focusing on these distinct anatomical subsites.

Methods

We pooled data from seven case-control studies from the Stomach Cancer Pooling (StoP) Project. Pooled odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) of GC risk across BMI categories (normal weight, overweight, obesity) were calculated by pooling study-specific ORs through random-effects meta-analytic models. The dose-response relationship between BMI and the risk of GC cancer was assessed by using a one-stage mixed-effects logistic regression model. Results were strati

SUBMITTER: Pastorino R 

PROVIDER: S-EPMC12476909 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature