The inflammatory potential of diet in adults with knee osteoarthritis: sex-specific associations with quality of life, sleep, fatigue and mental health.

ABSTRACT:

Background

Knee osteoarthritis (OA) is a disabling condition-characterized by pain, stiffness, and impaired quality of life-that affects more females than males. Chronic systemic inflammation is a key feature of knee OA and can be modulated by diet. We evaluated the sex-specific relationship between the inflammatory potential of diet and health-related quality of life (HRQOL), sleep quality, energy and fatigue levels, and psychological distress in individuals with knee OA.

Methods

This cross-sectional study analyzed baseline data from 144 participants (64% female) aged 45-85 years with symptomatic knee OA enrolled in the FEAST (eFEct of an Anti-inflammatory diet for knee oSTeoarthritis) randomized controlled trial, which compared an anti-inflammatory dietary program to a sta

SUBMITTER: Law L 

PROVIDER: S-EPMC12476995 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature