Efficacy of flavonoids in non-alcoholic fatty liver disease: an updated systematic review and meta-analysis.

ABSTRACT:

Background

Non-alcoholic fatty liver disease (NAFLD) is a common health challenge worldwide and urgently requires effective therapeutic interventions. Flavonoids, a diverse group of plant-derived polyphenols, have demonstrated multifaceted biological functions, like anti-inflammatory, antioxidant and metabolic regulatory capacities, suggesting their potential utility in the management of NAFLD.

Objective

This systematic review and meta-analysis aims to synthesize evidence from randomized controlled trials (RCTs) that examined the effects of flavonoid supplementation (including specific subclasses) in patients with NAFLD on liver function, markers of inflammation, lipid profiles, anthropometric measures and insulin resistance.

Methods

This study rigorously adhered to t

SUBMITTER: Liu Q 

PROVIDER: S-EPMC12477019 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature