Spatial transcriptomics reveals distinct role of monocytes/macrophages with high <i>FCGR3A</i> expression in kidney transplant rejections.

ABSTRACT:

Introduction

Kidney transplant rejections are classified as active antibody mediated rejection (AMR) and cell mediated rejection (TCMR), with AMR primarily driven by antibodies produced by B cells, whereas TCMR is mediated by T lymphocytes that orchestrate cellular immune responses against the graft. Emerging evidence highlights the essential roles of innate immune cells in rejections, especially monocytes/macrophages and natural killer (NK) cells. However, the roles of specific innate immune cell subpopulations in kidney allograft rejection remain incompletely understood.

Methods

We performed the spatial transcriptomics using the formalin-fixed paraffin-embedded (FFPE) core needle biopsies from human kidney allografts.

Results

We demonstrated that non-rejection, AMR,

SUBMITTER: Chen Wongworawat Y 

PROVIDER: S-EPMC12477047 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature