Regulators of RNA m⁵C methylation are adipose tissue depot-specific expressed and correlate with clinical variables of obesity in humans.

ABSTRACT:

Background

Obesity is a global health burden and recent evidence indicates that epitranscriptomic regulation is potentially involved in its etiology. The epitranscriptomic mark 5-methylcytosine (m⁵C) is implicated in cancer and recent data linked the gene expression of m⁵C writers, erasers and readers to diabetes, a well-known co-morbidity of obesity. Here, we tested whether gene expression of m⁵C regulators in paired samples of human visceral and subcutaneous adipose tissue is (i) adipose tissue depot-specific and (ii) correlates with important clinical variables of obesity.

Methods

Intra-individually paired adipose tissue samples from human subcutaneous adipose tissue (SAT) and omental visceral adipose tissue (OVAT) were utili

SUBMITTER: Svensson SIA 

PROVIDER: S-EPMC12477048 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature