Association of alcohol responsiveness and non-motor symptoms in isolated adult-onset dystonia.

ABSTRACT:

Objective

About 30% of patients with isolated adult-onset dystonia report an improvement of their motor symptoms after the consumption of alcohol. In this cross-sectional study, we sought to investigate whether the observed improvement is attributable to the anxiolytic, euphoric, and analgesic properties of alcohol, rather than or in addition to its effect on dystonic movements, as psychiatric symptoms and pain frequently occur in dystonia patients and as emotional stress is a well-established trigger for symptom exacerbation.

Methods

We analyzed data from 339 prospectively enrolled participants with recently diagnosed isolated dystonia (mean age: 55.2 ± 12.5 years, 228 female) of the Natural History Project of the Dystonia Coalition, a large international multicenter study.

SUBMITTER: Junker J 

PROVIDER: S-EPMC12477084 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature