Pediatric acute respiratory distress syndrome in children with type I - spinal muscular atrophy: a 12-year case series.

ABSTRACT: Spinal muscular atrophy type 1 (SMA-1), a disease affecting the lower motor neurons in the anterior horn cells, causes substantial respiratory morbidity and mortality in children. While recent advances in disease modifying treatments (DMTs) have improved survival and quality of life in these patients, the management and outcomes of pediatric acute respiratory distress syndrome (pARDS) in SMA-1 children have not yet been described. To report the clinical outcome and characteristics of a group of children affected by SMA-1 suffering from the most serious acute respiratory disease, i.e., pARDS, we conducted a retrospective case series of 18 SMA-1 patients with pARDS admitted to a pediatric intensive care unit over a 12-year period (2010-2021). Parameters collected included demographics, clini

SUBMITTER: Piastra M 

PROVIDER: S-EPMC12477088 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature