PET microplastics alter the transcriptome profile and oxidative stress markers in the liver of immature piglets: an in vivo study.

ABSTRACT: The increasing global contamination with microplastics (MPs) poses a significant threat to human and animal health. Recent studies suggest that exposure to microplastics contributes to various detrimental hepatic effects, including oxidative stress and metabolic dysregulation. The aim of the present study was to investigate the global liver transcriptome, oxidative stress and selected liver function markers in immature piglets (n = 15) exposed to polyethylene terephthalate (PET) MPs for 4 weeks. The animals were divided into three groups: a low-dose MPs exposure group (0.1 g PET MPs/day), a high-dose MPs exposure group (1 g PET MPs/day), and a control group that did not receive MPs. The transcriptome profile of the liver was assessed using RNA-Seq. In addition, markers of oxidative stress

SUBMITTER: Golubska M 

PROVIDER: S-EPMC12477095 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature