Visceral Adiposity Thresholds for Cardiovascular Risk Stratification: A Simplified Biomarker-Driven Model.

ABSTRACT:

Objective

VAT volume is a critical determinant of cardiometabolic risk, yet population-specific thresholds and accessible predictive tools remain undefined.

Methods

Using US National Health and Nutrition Examination Survey (NHANES) data, we analyzed dual-energy x-ray absorptiometry (DXA)-derived VAT volume. Threshold effects and sex/ethnicity interactions were evaluated via multivariable regression, while LASSO regularization and ROC analyses identified a simplified predictive model.

Results

A VAT volume threshold of 327.0 cm³ stratified CVD risk, distinguishing compensatory from pathological adiposity. The high-VAT group exhibited elevated CVD prevalence (2.41% vs. 1.12%, p = 0.016), metabolic dysregulation, and socioeconomic disparities. Males showed high

SUBMITTER: Guo T 

PROVIDER: S-EPMC12477109 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature