L-shaped association of low-density lipoprotein cholesterol with all-cause and cardiovascular mortality in cancer survivors: a population-based cohort study.

ABSTRACT:

Objectives

To evaluate the association between LDL-C levels and all-cause, cardiovascular, and cancer mortality in cancer survivors, and to identify the LDL-C level associated with the lowest mortality risk, using data from NHANES 1999-2018.

Study design

Population-based cohort study.

Methods

We analyzed 1,958 U.S. cancer survivors from the National Health and Nutrition Examination Survey (NHANES) 1999-2018. We used Cox and Fine-Gray model to compare mortality risks across LDL-C quartiles, combined with restricted cubic spline analysis to assess nonlinear relationships, and piecewise linear regression to identify LDL-C inflection points.

Results

During a median follow-up of 7.3 years (681 deaths were recorded), we observed a nonlinear association between LDL-C

SUBMITTER: Hou B 

PROVIDER: S-EPMC12477126 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature