Cytotoxic CD4⁺ T-follicular cells may mediate killing against lymphoma cells.

ABSTRACT: Recently, we have identified CD4⁺PD-1⁺CXCR5⁺ T-follicular helper (T_FH) cells with a distinct cytotoxic phenotype and named them "killer T_FH (T_{F K} )" cells. In this study, we aim to elucidate their presence and functional relevance in two different lymphoma subtypes, follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). Flow cytometric analysis of tonsillar versus FL-cell suspensions revealed a heightened number of GZMK⁺NKG7/TIA-1⁺ T_{F K} cells in the latter, accompanied by a significant increase in T-regulatory and T-follicular regulatory (T_FR) cells. In contrast, DLBCL exhibited a decrease in T_FH and T_FR cell nu

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC12477175 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature