Morphological and quantitative CT features of anterior mediastinal lesions in TAFRO syndrome and idiopathic multicentric Castleman disease.

ABSTRACT: We investigated the diagnostic challenges of TAFRO syndrome and idiopathic multicentric Castleman disease (iMCD), focusing on the usefulness of anterior mediastinal lesions for distinguishing the disease subtypes. A comparative analysis using computed tomography (CT) imaging was performed for three patient groups: TAFRO without iMCD/iMCD-TAFRO (n=13), iMCD-idiopathic plasmacytic lymphadenopathy (IPL)- not otherwise specified (NOS) (n=16), and IgG4-related disease (IgG4-RD) (n=59). Lesions were categorized into increased fat density, micronodular opacity, and mass. The lesions' CT attenuation values were compared, and receiver operating characteristic (ROC) curve analyses assessed their diagnostic relevance. Anterior mediastinal lesions were most frequent in the TAFRO without iMCD/iMCD-TAFR

SUBMITTER: Mohamed L 

PROVIDER: S-EPMC12477180 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature