Composition of cardiac-derived extracellular vesicles changes with vesicle origin and determines uptake.

ABSTRACT:

Introduction

Cardiovascular disease (CVD) is a leading cause of mortality worldwide. The potency of cell-based therapies for CVD is increasingly attributed to the release of small extracellular vesicles (sEVs) which consist of a lipid/protein membrane and encapsulate nucleic cargo. Specifically, sEVs from ckit + progenitor cells (CPCs) and mesenchymal stromal cells (MSCs) are shown to be pro-reparative, with clinical trials conducted. Despite copious research into sEV cargo, the role of parent cell type on sEV membrane composition and its effects on sEV uptake mechanism by recipient cells remain unclear. This is crucial for designing sEV-based therapeutics as uptake mechanism dictates the functionality of the cargo.

Methods

In this study we investigate the role of sEV parent

SUBMITTER: Bheri S 

PROVIDER: S-EPMC12477219 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature