Assessing the translation of diagnostic colorectal cancer biomarkers from bench to bedside.

ABSTRACT:

Background

Colorectal cancer is the second leading cause of cancer mortality worldwide. Evidence demonstrates that screening identifies patients with earlier disease to improve survival. It is imperative that diagnostic biomarkers are efficiently translated to clinical practice.

Aim

We aimed to assess the state of biomarker translation by comparing the number of diagnostic colorectal cancer biomarkers in clinical use (successful) with the total number of discovered diagnostic colorectal cancer biomarkers not yet clinically useful (stalled).

Method

A literature search identified all published diagnostic colorectal cancer biomarkers. Data was extracted from eligible papers including biomarker name, authors, journal and impact factor, and publication date. Guidelines fro

SUBMITTER: Baggaley AE 

PROVIDER: S-EPMC12477240 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature