The diverse <i>N</i>-glycosylation profiles of CD4⁺CD25^- and CD4⁺CD25⁺ T cells in Hashimoto's thyroiditis.

ABSTRACT: Hashimoto's thyroiditis (HT) is one of the most common organ-specific autoimmune diseases, characterized by chronic thyroid gland inflammation. Helper T (Th) CD4⁺ cells, whose surface receptors are highly glycosylated, are involved in the pathomechanism of HT. Our study aimed to characterize N-glycosylation profiles in two pools of CD4⁺ T cells, defined by the expression of CD25⁺ late activation marker (CD4⁺CD25⁺) and CD25-negative cells (CD4⁺CD25^-) in HT. Two study groups were recruited: HT1 with elevated thyroid autoantibodies and TSH level within the normal range without hypothyroidism, and HT2, hypothyroid HT patients, adequately metabolically controlled while on L-thyroxine replacement therapy, and hea

SUBMITTER: Trzos S 

PROVIDER: S-EPMC12477247 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature