Comparative single-cell immune responses in peripheral blood and lymph node of immunized SARS-CoV-2 challenged infant rhesus macaques.

ABSTRACT:

Introduction

A better understanding of post-exposure immune responses in vaccinated individuals, particularly infants, is needed.

Methods

Using a rhesus macaque model, we compared recipients of mRNA- or protein-based SARS-CoV-2 vaccines administered in infancy with unvaccinated controls 7 days post-SARS-CoV-2 virus challenge. Mass cytometry profiling of peripheral blood mononuclear cells and dissociated mediastinal lymph node cells at 7 days post-challenge revealed tissue-specific differences between groups, representing a snapshot of immune activity at this point.

Results

Vaccinated animals showed lower frequencies of activated CD8+ T cells in blood and lower levels of monocyte and B cell subsets in lymph nodes, aligning with lower viral loads and milder pathology. P

SUBMITTER: Anronikov S 

PROVIDER: S-EPMC12477255 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature